StudentShare
Contact Us
Sign In / Sign Up for FREE
Search
Go to advanced search...

Regulation of Aldosterone - Essay Example

Cite this document
Summary
The essay "Regulation of Aldosterone" focuses on the critical analysis of the regulation of Aldosterone. It is a mineralocorticoid steroid hormone regulating Na+ and K+ balance in the blood. Aldosterone is a mineralocorticoid steroid hormone regulating Na+ and K+ balance in the blood…
Download full paper File format: .doc, available for editing
GRAB THE BEST PAPER98.6% of users find it useful
Regulation of Aldosterone
Read Text Preview

Extract of sample "Regulation of Aldosterone"

Download file to see previous pages Aldosterone secretion is regulated by multiple factors including the renin-angiotensin system (RAS), the level of K+ and Na+ ions in the blood, such hormones as ACTH, vasopressin, and somatostatin, serotonin, dopamine, atrial natriuretic peptide (ANP), β-adrenergic agents, etc (Wehling, 1995; Goodfriend, 2006).

Renin is an enzyme catalyzing the reaction of the transformation of angiotensinogen into angiotensin I. Angiotensin I is converted into angiotensin II and the last one is partially converted into angiotensin III (Wehling, 1995).

Both angiotensin II and III stimulate the synthesis of aldosterone by the adrenal glomerulosa layer. They bind to G-protein coupled receptors and stimulate the activity of phospholipase C and adenylate cyclase. This results in the increase of conversion of cholesterol to pregnenolone and corticosterone to aldosterone (Horton, 1994; Fuller, 2006).

The role of other factors is presented in the following table:

Increase of aldosterone synthesis

Decrease of aldosterone synthesis

Potassium

ACTH

Vasopressin

Sodium

Dopamine

Atrial natriuretic peptide (ANP)

Aldosterone controls electrolyte excretion and intravascular fluid volume. It acts on the mineralocorticoid receptors of the distal renal tubules and cortical collecting ducts of the kidneys. Aldosterone regulates such physiological mechanisms as resorption and excretion of electrolytes, particularly its action increases sodium resorption and potassium excretion. Sodium and water reabsorption is regulated by opening Na+ channels in the apical membranes of the tubular epithelium (Fuller, 2006; Rosansky, 2006). Correspondingly, opening K+ channels leads to increased potassium conductance from the cell and potassium excretion.

Aldosterone receptors are localized intracellularly. Their stimulation leads to DNA binding and changes in the transcription of genes.

Interestingly, aldosterone does not only participate in the regulation of blood pressure but it also influences the function of mononuclear leukocytes (Chai, 2005; Wehling, 1995).

...Download file to see next pages Read More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Aldosterone Essay Example | Topics and Well Written Essays - 1000 words”, n.d.)
Aldosterone Essay Example | Topics and Well Written Essays - 1000 words. Retrieved from https://studentshare.org/miscellaneous/1511117-aldosterone
(Aldosterone Essay Example | Topics and Well Written Essays - 1000 Words)
Aldosterone Essay Example | Topics and Well Written Essays - 1000 Words. https://studentshare.org/miscellaneous/1511117-aldosterone.
“Aldosterone Essay Example | Topics and Well Written Essays - 1000 Words”, n.d. https://studentshare.org/miscellaneous/1511117-aldosterone.
  • Cited: 0 times

CHECK THESE SAMPLES OF Regulation of Aldosterone

Urinary and digestive systems

Increased secretion of aldosterone results in increased re-absorption of sodium ions in the kidneys which increases the osmolality.... The adrenal cortex secretes aldosterone which is important in water balance.... Mechanism of secretion of hydrogen ions in the renal system Hydrogen ions in the body are produced by the normal metabolic processes....
4 Pages (1000 words) Essay

Adrenal Cortex and Adrenal Medulla in the Endocrine Response to Stress

Physiologic effects of glucocorticoids include regulation of protein, carbohydrate, lipid, and nucleic acid metabolism.... These hormones are glucocorticoids, aldosterone, and adrenal androgens.... Introduction: Each adrenal gland is, in effect, structurally and functionally two endocrine glands in one in that it is comprised of an outer cortex surrounding an inner medulla....
6 Pages (1500 words) Essay

Regulation of Physiological Process by Thyroid Hormones

Their functions include reproduction and sexual differentiation, development and growth, maintenance of the internal environment, and regulation of metabolism and nutrient supply (Nussey & Whitehead 2001).... They stimulate the oxygen consumption of most of the cells of the body, help in the regulation of lipid and carbohydrate metabolism, and are essential for normal growth and maturation....
7 Pages (1750 words) Essay

Interconnectivity of organ systems

This paper explores the concept of organ interconnectivity during the regulation of blood pressure and hypertension.... The connectivity of the organs involved in the regulation of blood pressure is evident as early as during the causative stages of high blood pressure....
4 Pages (1000 words) Research Paper

Potassium Regulation of the Heart and Cardiovascular System

The paper "Potassium regulation of the Heart and Cardiovascular System" states that elevated potassium levels can cause a shift in the connection between blood pressure and sodium excretion that will eventually lead to a decrease in arterial blood pressure.... ... ... ... The cardiovascular system of the human body consists of the heart, blood vessels e....
4 Pages (1000 words) Term Paper

ENaC and Hypertension

Hyperactivity of aldosterone secretion is referred to as primary aldosteronism and the result of this process is the occurrence of arterial hypertension [14].... The lack of aldosterone production contributes to salt wasting and hypotension in these individuals [33].... Further, we also characterize the profile of expression in a family with 21- Hydroxylase Deficiency which causes salt wasting owing to the absence of aldosterone expression....
1 Pages (250 words) Essay

Biomedical Science: Pathophysiology of Disease

The cortex is secreted aldosterone, sex hormones, and cortisol.... "Biomedical Science: Pathophysiology of Disease" paper identifies what is the most probable diagnosis in the patient based on the patient's clinical presentation and laboratory results, and explains the hyponatremia, decreased bicarbonate and decreased serum osmolality....
7 Pages (1750 words) Case Study

The Effect of Cystic Fibrosis on the Process of Digestion and the Processes of Glycolysis

"Effect of Cystic Fibrosis on the Process of Digestion and the Processes of Glycolysis" paper describes the role of the renin-angiotensin system in trying to maintain blood volume and blood pressure and how processes of glycolysis and gluconeogenesis contribute to the blood glucose level regulation....
11 Pages (2750 words) Assignment
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Contact Us