StudentShare
Contact Us
Sign In / Sign Up for FREE
Search
Go to advanced search...
Free

Physiology - Research Paper Example

Cite this document
Summary
The research report by Bender, Uebele, Renger and Trussell delves into the scientific phenomena that investigate the control of firing patterns through modulation of axon initial segment T-type calcium channels. In this regard, the authors recognize the important role played by…
Download full paper File format: .doc, available for editing
GRAB THE BEST PAPER92.4% of users find it useful
Physiology research paper
Read Text Preview

Extract of sample "Physiology"

Human Physiology: Research Paper summary report The research report by Bender, Uebele, Renger and Trussell delves into the scientific phenomena that investigate the control of firing patterns through modulation of axon initial segment T-type calcium channels. In this regard, the authors recognize the important role played by spontaneous bursting of neurons through fire clusters exhibited in the action potentials. Evidently, this mechanism contributes to the functions of various neurons such as sleep rhythms and breathing.

However, the article recognizes the deficiency in sufficient knowledge pertaining to the cellular mechanism which contributes to the spontaneous burst generation. In this regard, the articles primary focus was to establish the functioning underlying the aforementioned cellular mechanism. To this end, one of the methods used was electrophysiology in which all the procedures were concordant to the OHSU IACUC guidelines. This method was soon followed by a procedural process of perforated-patch recordings.

The third method or procedure entailed targeted iontophoresis of Ni2+ or Na+. The primary chemicals used in the process were Alexa Fluor 594 hydrazide Na+ salt and Fluo-5F pentapotassium salt derived from Invitrogen. GF-109203X and (-) –Quinpirole hydrochloride were from Tocris Bioscience (Ellisville,MO,USA), NBQX, R-CPP, D- AP5, and SR95531 were derived from Ascent Bristol. The remaining chemicals were derived from Sigma-Aldrich. Finally, all the statistical data were tabulated as means ± standard error of the mean (SEM).

In addition, an ANOVA in tandem with a Mann-Whitney U test was used. Furthermore, Kolmogorov-Smirnov (KS) test were changed to cumulatice probability distributions. To this end, the findings indicated that calcium-permeable ion channels played a pertinent role in the generation of spontaneous bursts within the auditory brainstem neurons. In this regard, the research exhibited that T-type Ca 2+ channels that were concentrated on the site of action potential initiation in the axon initial area plays a pertinent role in the spontaneous burst creations.

Moreover, the calcium influx resulting evident as a block in the auditory system neuron was enough in the conversion of neurons bursting spontaneously within the neurons that fired and exhibited a regular pattern. Evidently, within the auditory brainstem interneurons, the influx of axon initial segment is down-regulated selectively through signalling of dopamine. The research equally showed that the block of calcium could be mediated through the assistance of the neurotransmitter dopamine that changes the activity of calcium via a kinase dependent mechanism.

The regulation do Ca2+ influx has indicated the effects of spontaneous action that converts the predominant mode of spontaneous action form the bursts of regular spiking. To this end, the results have been recognised as the pioneer evidence of spontaneous firing mode that is controlled by the action of neuromodulators that are concentrated within a particular cellular compartment. In addition, they highlight the pertinent role of calcium channels in the creation of a spontaneous neuronal rhythm.

Consequently, the general conclusions of the research indicated that the axon initial segment was a key location, and the dopamine was an important regulator of spontaneous bursting activity.ReferenceBender, Kevin J. , Laurence O. Trussel, John J. Renger , and Victor N. Uebele . "Control of firing patterns through modulation of axon initial segment T-type calcium channels." J.Physiol 590.1 (2012): 109-118. Print.

Read More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Physiology research paper Example | Topics and Well Written Essays - 500 words - 1”, n.d.)
Physiology research paper Example | Topics and Well Written Essays - 500 words - 1. Retrieved from https://studentshare.org/miscellaneous/1621206-physiology-research-paper
(Physiology Research Paper Example | Topics and Well Written Essays - 500 Words - 1)
Physiology Research Paper Example | Topics and Well Written Essays - 500 Words - 1. https://studentshare.org/miscellaneous/1621206-physiology-research-paper.
“Physiology Research Paper Example | Topics and Well Written Essays - 500 Words - 1”, n.d. https://studentshare.org/miscellaneous/1621206-physiology-research-paper.
  • Cited: 0 times

CHECK THESE SAMPLES OF Physiology research paper

The affect of temperature as an environmental pressure that affects mammalian life

This paper highlights various research studies that have helped in supporting this thesis by proving the effect of temperature on mammalian microevolution, habitat distribution and overall physiologic processes such as growth.... A research by Kaufmann et al (2000), found that mammalian cell proliferation can be controlled by changing cell cultivation temperatures.... The research revealed that the shifts in temperature affects protein formation, especially; at the translation stage of protein expression....
3 Pages (750 words) Research Paper

Interaction of Brain and Insulin

In this tiny research paper goes about functions of insulin, different associated with this substance diseases and the brain response.... The research paper "Interaction of brain and insulin" breaks the outdated and non-actual information about brain and insulin connection and their paired role in our homeostasis.... All work is based on basic human physiology laws and data of modern functional researches with the help of fMRI and biochemistry....
4 Pages (1000 words) Research Paper

Physiology of Development and Germination

The paper presents seed germination which is a complex phenomenon involving many physiological and biochemical changes and leading to the activation of the embryo.... Five rectangular plates (12”x5”) will be lined with paper towels pre-moistened by different solutions.... In the next three days, the paper towels in the plates will be moistened twice a day (10 AM and 4 PM) with the appropriate salt solution to prevent water loss due to evaporation....
5 Pages (1250 words) Research Paper

Development of Simulated Intestinal Fluids

The paper "Development of Simulated Intestinal Fluids" explores the ideal transport medium containing appropriate nutrients, which could support the Caco-2 cell culture model thereby facilitating the transport of traditionally hydrophobic molecules like estradiol and etoposide.... They have analyzed the previous studies well and the paper elaborates upon the various approaches tried and the success or failures thereof in the introduction itself.... They have analyzed the previous studies well and the paper elaborates upon the various approaches tried and the success or failures thereof in the introduction itself....
5 Pages (1250 words) Research Paper

Apraxia of Speech: An overview

I strongly believe that the paper encourages more in depth study of the subject so that new variant of AOS could be identified.... The research shows that efficacy of treatment mainly relies on experimental designs as per the needs of the patients.... The article, ‘Apraxia of Speech: An Overview' by Ogar et al....
2 Pages (500 words) Research Paper

Effect of Ocean acidification upon ability to adapt to climate change in Nereis species

Nereis zonata also has the ability to survive in low pH areas, if conclusions made after research on the relationship between Nereis Zonata and the level of organic enrichment of the sea-water holds (Murphy & Measures, 2014, 442).... The patterns of response as observed after research may have been arrived at through either adaptation or acclimatization.... It is a fact that organisms may have the ability to change their physiology through phenotypic plasticity, also known acclimatization (Armstrong, 2013, 593)....
6 Pages (1500 words) Research Paper

Alchemy and Remedy in Higher Education

research paper: Test Evaluations Psychometric tests involve a wide array of tools for evaluating one's personality, knowledge, abilities, attitudes or educational measurements (The American Psychological Association 1999).... The paper “Alchemy and Remedy in Higher Education” looks at psychometric tests, which involve a wide array of tools for evaluating one's personality, knowledge, abilities, attitudes or educational measurements.... research shows that the utility and validity of projective tests is lower than objective tests because some are more time consuming in comparison to the objective tests....
2 Pages (500 words) Research Paper

The Achievements of Jewish Immigrants in the UK between 1900-1950

… The paper "The Achievements of Jewish Immigrants in the UK between 1900-1950 " is an outstanding example of a history research paper.... The paper "The Achievements of Jewish Immigrants in the UK between 1900-1950 " is an outstanding example of a history research paper.... This paper will show how famous Jews have successfully been recognized in the fields of science, business, and music.... He not only contributed greatly to the business industry in the UK, as his company provided thousands of jobs, he also helped in other fields, such as the medical research community....
2 Pages (500 words) Research Paper
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Contact Us